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Explore›Medical Conditions in Dentistry›Von Willebrand disease

Von Willebrand disease

Dental riskmoderate

Von Willebrand disease (vWD) is the MOST COMMON inherited bleeding disorder, caused by quantitative and/or qualitative problems in von Willebrand factor (vWF), often with secondary low factor VIII. Bleeding is typically MUCOSAL (epistaxis, menorrhagia, gum bleeding) and procedure-related. Management: (1) DDAVP (desmopressin) in responsive patients, (2) vWF concentrates when DDAVP unsuitable/ineffective, (3) tranexamic acid (TXA) as adjunct, (4) local hemostatic measures always. ASH/ISTH/NHF/WFH 2021 guideline is the primary reference. Key dental principle: the special protocol is HEMOSTASIS, not antibiotics.

The full condition entry includes

  • Safe vs avoid lists: antibiotics, analgesics, local anesthetics
  • Vasoconstrictor limits and treatment modifications
  • Pre/intra/post-op monitoring and deferral criteria
  • Emergency management, explained for study
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