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Explore›Medical Conditions in Dentistry›Osteoporosis on antiresorptives (MRONJ risk)

Osteoporosis on antiresorptives (MRONJ risk)

Dental riskhigh

Medication-related osteonecrosis of the jaw (MRONJ) is exposed bone (or bone probeable through a fistula) in the maxillofacial region persisting >8 weeks in a patient exposed to antiresorptive or antiangiogenic agents, without head/neck radiation. Risk is stratified by indication: osteoporosis dosing (oral bisphosphonates like alendronate — MRONJ is RARE) vs oncology dosing (high-dose IV bisphosphonates/denosumab — much HIGHER risk). AAOMS 2022 position paper is the major reference. Prevention strategy: risk assessment + atraumatic technique + oral health optimization.

The full condition entry includes

  • Safe vs avoid lists: antibiotics, analgesics, local anesthetics
  • Vasoconstrictor limits and treatment modifications
  • Pre/intra/post-op monitoring and deferral criteria
  • Emergency management, explained for study
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More medical conditions in dentistry

Hypertension (uncontrolled / hypertensive urgency)Ischemic heart disease (stable angina, recent/old MI)Heart failure (compensated vs decompensated)Valvular heart disease / Prosthetic heart valvesPatients on anticoagulants/antiplateletsCongenital heart disease (high-risk lesions/repairs)Pulmonary hypertensionCOPD (moderate-severe; oxygen dependence)Active upper respiratory infection (URI)Chronic hypoxemia / home oxygen patientsInterstitial lung disease / pulmonary fibrosisStroke / TIA history

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