Cell cycle and cell death

Why this matters

Oral epithelium renews continuously, wounds recruit controlled proliferation, development removes temporary cells and severe injury can cause cell death. The same control systems become clinically important in oral cancer and treatment-related tissue injury.

You will be able to

1. 1.Sequence G1, S, G2 and M phase.
2. 2.Explain cyclin-CDK control and checkpoints.
3. 3.Track chromosome behaviour through mitosis.
4. 4.Distinguish quiescence and cellular senescence.
5. 5.Compare apoptosis with necrotic cell death.
6. 6.Connect failed controls to cancer biology.

The 12 cards in this lesson

1. 01Four active phases organise one cell division
2. 02Not cycling does not describe one single cell state
3. 03The checkpoint-and-fate map
4. 04Cyclin-CDK complexes drive ordered transitions
5. 05Checkpoints delay transitions when key tasks are incomplete
6. 06Mitosis separates one replicated genome into two nuclei
7. 07Senescence stops division but leaves an active cell
8. 08Apoptosis dismantles a cell through regulated proteolysis
9. 09Necrosis is a morphology, not one universal mechanism
10. 10Uncontrolled proliferation reflects failed balance
11. 11Cancer is an evolving malignant tissue system
12. 12Cell fate across dental biology

You have got it when

You are ready to continue when you can locate a cell-cycle event, identify the checkpoint that tests it, predict whether the cell repairs, arrests or dies, and explain why uncontrolled proliferation alone does not define all of cancer biology.